Alcoa Foundation Hall of American Indians explores Native American cultures in an exhibit organized around their relationships with the natural world. These relationships are illustrated through case studies of societies living in four major geographical areas - the Tlingit of the Northwest Coast, Hopi of the Southwest, Lakota of the Plains, and Iroquois of the Northeast.

The Hall of American Indians engages visitors through variety of exhibit techniques. These objects "come to life" in a dynamic environment boasting highly realistic dioramas illustrating American Indian lifestyles, eight audio programs, nine short video presentations, two interactive computer activities, and a planetarium-style theater that tells the story of how the stars got in to the heavens.

Other highlights include a re-creation of a Hopi house; a video theater featuring Native storytellers; a detailed, miniature reproduction of Cornplanter's Grant, a tract of Iroquois-owned land along the Allegheny River; and a Plains landscape with a touchable buffalo.